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CPA4 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CPA4 Antibody (C-term) AP7338b
    Western blot analysis of CPA4 antibody (C-term) (Cat.#AP7338b) in Hela, CEM and NCI-H460 cell line lysates (35ug/lane). CPA4 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UI42
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47351 Da
Antigen Region 305-336 aa
Additional Information
Gene ID 51200
Other Names Carboxypeptidase A4, 3417-, Carboxypeptidase A3, CPA4, CPA3
Target/Specificity This CPA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the C-terminal region of human CPA4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPA4
Synonyms CPA3
Function Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563).
Cellular Location Secreted.
Tissue Location Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele
Research Areas
Citations (0)
citation

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Background

CPA4 is a member of the carboxypeptidase A/B subfamily. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This protein could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate protein for prostate cancer aggressiveness.

References

Ross,P.L., Cheng,I. BMC Cancer 9, 69 (2009)
Bentley,L., Nakabayashi,K. J. Med. Genet. 40 (4), 249-256 (2003)
Kayashima,T., Yamasaki,K. Hum. Genet. 112 (3), 220-226 (2003)
Hayashida,S., Yamasaki,K. Genomics 66 (2), 221-225 (2000)

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$ 365.00
$ 140.00
Cat# AP7338b
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