|Application ||WB, E|
|Calculated MW||47351 Da|
|Antigen Region||305-336 aa|
|Other Names||Carboxypeptidase A4, 3417-, Carboxypeptidase A3, CPA4, CPA3|
|Target/Specificity||This CPA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the C-terminal region of human CPA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloprotease that could be involved in the histone hyperacetylation pathway.|
|Tissue Location||Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele|
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Provided below are standard protocols that you may find useful for product applications.
CPA4 is a member of the carboxypeptidase A/B subfamily. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This protein could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate protein for prostate cancer aggressiveness.
Ross,P.L., Cheng,I. BMC Cancer 9, 69 (2009)
Bentley,L., Nakabayashi,K. J. Med. Genet. 40 (4), 249-256 (2003)
Kayashima,T., Yamasaki,K. Hum. Genet. 112 (3), 220-226 (2003)
Hayashida,S., Yamasaki,K. Genomics 66 (2), 221-225 (2000)
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