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CP Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 4
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P00450 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 122219 Da |
| Antigen Region | 121-151 aa |
| Gene ID | 1356 |
|---|---|
| Other Names | Ceruloplasmin, Ferroxidase, CP |
| Target/Specificity | This CP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-151 amino acids from the N-terminal region of human CP. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CP (HGNC:2295) |
|---|---|
| Function | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo- transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:5912351, PubMed:14623105). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). |
| Cellular Location | Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments {ECO:0000250|UniProtKB:P13635} |
| Tissue Location | Expressed by the liver and secreted in plasma. |
Provided below are standard protocols that you may find useful for product applications.
Background
CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this protein cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.
References
Park,Y., Lee,I.S. Arch. Pharm. Res. 32 (5), 693-698 (2009)
Altamura,C., Squitti,R. Stroke 40 (4), 1282-1288 (2009)
Squitti,R., Quattrocchi,C.C. Prion 2 (1), 23-27 (2008)
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