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BCOR Antibody (Center S1122)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BCOR Antibody (Center S1122) AP7359c
    Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in 293 cell line lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.
  • WB - BCOR Antibody (Center S1122) AP7359c
    Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in mouse stomach tissue lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.
  • IHC-P - BCOR Antibody (Center S1122) AP7359c
    BCOR Antibody (Center S1122) (Cat.# AP7359c) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCOR Antibody (Center S1122) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - BCOR Antibody (Center S1122) AP7359c
    BCOR Antibody (Center S1122) (Cat. #AP7359c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6W2J9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 192189 Da
Antigen Region 1107-1137 aa
Additional Information
Gene ID 54880
Other Names BCL-6 corepressor, BCoR, BCOR, KIAA1575
Target/Specificity This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1107-1137 amino acids from the Central region of human BCOR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCOR Antibody (Center S1122) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1575
Function Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Citations (0)

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BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs.


Ghetu,A.F., Mol. Cell 29 (3), 384-391 (2008)
Hilton,E.N., Hum. Mol. Genet. 16 (14), 1773-1782 (2007)

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Cat# AP7359c
(40 western blots)
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