|Application ||WB, IHC-P, FC, E|
|Calculated MW||192189 Da|
|Antigen Region||1107-1137 aa|
|Other Names||BCL-6 corepressor, BCoR, BCOR, KIAA1575|
|Target/Specificity||This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1107-1137 amino acids from the Central region of human BCOR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCOR Antibody (Center S1122) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs.
Ghetu,A.F., Mol. Cell 29 (3), 384-391 (2008)
Hilton,E.N., Hum. Mol. Genet. 16 (14), 1773-1782 (2007)
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