|Application ||WB, IHC-P, FC, E|
|Other Accession||P29457, P19324, Q2KJH6|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||46441 Da|
|Antigen Region||169-196 aa|
|Other Names||Serpin H1, 47 kDa heat shock protein, Arsenic-transactivated protein 3, AsTP3, Cell proliferation-inducing gene 14 protein, Collagen-binding protein, Colligin, Rheumatoid arthritis-related antigen RA-A47, SERPINH1, CBP1, CBP2, HSP47, SERPINH2|
|Target/Specificity||This SERPINH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-196 amino acids from the Central region of human SERPINH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CBP1, CBP2, HSP47, SERPINH2|
|Function||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.|
|Cellular Location||Endoplasmic reticulum lumen.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.
Araki,K., Br. J. Cancer 101 (3), 492-497 (2009)
Katagata,Y., J. Dermatol. Sci. 49 (1), 33-38 (2008)
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