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CATB Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7367c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CATB Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P07858 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 37822 Da |
CATB Antibody (Center) - Additional info | |
| Gene ID 1508 | |
| Other Names CTSB; CPSB; Cathepsin B; APP secretase; Cathepsin B1; Cathepsin B light chain; Cathepsin B heavy chain | |
| Target/Specificity This CATB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205~235 amino acids from the Center region of human CATB. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CATB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CATB Antibody (Center) - Protein Information | |
| Name CTSB | |
| Synonyms CPSB | |
| Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | |
| Cellular Location Lysosome. Melanosome. Secreted, extracellular space (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV | |
CATB Antibody (Center) - Related products
AP7367c: CATB Antibody (Center)
CATB Antibody (Center) - Application data
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Western blot analysis of CATB Antibody (Center) (Cat.# AP7367c) in Y79 cell line lysates (35ug/lane). CATB (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma with CATB Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of HepG2 cells using CATB Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
CATB Antibody (Center) - Research Areas
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BACKGROUND
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
REFERENCES
Zhang,H., J. Immunol. 182 (11), 6993-7000 (2009) Duncan,J.A., J. Immunol. 182 (10), 6460-6469 (2009)
