CTSS Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P25774 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37496 Da |
Antigen Region | 210-240 aa |
Gene ID | 1520 |
---|---|
Other Names | Cathepsin S, CTSS |
Target/Specificity | This CTSS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human CTSS. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CTSS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTSS |
---|---|
Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
Cellular Location | Lysosome. Secreted. Cytoplasmic vesicle, phagosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein CTSS, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The protein can function as an elastase over a broad pH range in alveolar macrophages.
References
Lindahl,C., Cancer Genomics Proteomics 6 (3), 149-159 (2009)
Bunatova,K., Int. J. Biol. Markers 24 (1), 47-51 (2009)
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