|Application ||WB, IHC-P, E|
|Calculated MW||36842 Da|
|Antigen Region||125-156 aa|
|Other Names||Fructose-1, 6-bisphosphatase 1, FBPase 1, D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, Liver FBPase, FBP1, FBP|
|Target/Specificity||This FBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-156 amino acids from the Central region of human FBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||FBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.|
|Tissue Location||Expressed in pancreatic islets.|
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Provided below are standard protocols that you may find useful for product applications.
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
Visinoni,S., Am. J. Physiol. Endocrinol. Metab. 295 (5), E1132-E1141 (2008)
Kebede,M., Diabetes 57 (7), 1887-1895 (2008)
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