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IMPDH2 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7390a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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IMPDH2 Antibody (N-term) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P12268 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 55805 Da |
IMPDH2 Antibody (N-term) - Additional info | |
| Gene ID 3615 | |
| Other Names IMPDH2; IMPD2; Inosine-5'-monophosphate dehydrogenase 2; IMPDH-II | |
| Target/Specificity This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115~145 amino acids from the N-terminal region of human IMPDH2. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions IMPDH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
IMPDH2 Antibody (N-term) - Protein Information | |
| Name IMPDH2 | |
| Synonyms IMPD2 | |
| Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors | |
| Cellular Location Cytoplasm. Nucleus. | |
| Tissue Location IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor | |
IMPDH2 Antibody (N-term) - Related products
AP7390a: IMPDH2 Antibody (N-term)
AP7390c: IMPDH2 Antibody (Center)
RI12725: IMPDH2 predesign siRNA
DC01876: Human IMPDH2 cDNA Clone
LY11571a: IMPDH2 Over-expression Lysate
BP7390a: IMPDH2 Antibody (N-term) Blocking Peptide
BP7390c: IMPDH2 Antibody (Center) Blocking Peptide
IMPDH2 Antibody (N-term) - Application data
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Western blot analysis of IMPDH2 Antibody (N-term) (Cat.# AP7390a) in NCI-H460 cell line and mouse lung tissue lysates (35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.
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IMPDH2 Antibody (N-term) (Cat.# AP7390a) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMPDH2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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IMPDH2 Antibody (N-term) (Cat. #AP7390a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
IMPDH2 Antibody (N-term) - Research Areas
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BACKGROUND
IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
REFERENCES
Sombogaard,F., Pharmacogenet. Genomics 19 (8), 626-634 (2009) Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)
