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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IMPDH2 Antibody (Center)   

IMPDH2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IMPDH2 Antibody (Center) AP7390c
    Western blot analysis of IMPDH2 Antibody (Center) (Cat. #AP7390c) in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.
  • IHC-P - IMPDH2 Antibody (Center) AP7390c
    IMPDH2 Antibody (Center) (Cat. #AP7390c) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMPDH2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - IMPDH2 Antibody (Center) AP7390c
    IMPDH2 Antibody (Center) (Cat. #AP7390c) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12268
Other Accession E9PU28, P24547, B0UXP9, P12269, Q3SWY3, D3ZLZ7, P50096, P20839, A0JNA3
Reactivity Human
Predicted Bovine, Mouse, Rat, Hamster, Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55805 Da
Antigen Region 180-210 aa
Additional Information
Gene ID 3615
Other Names Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD2
Target/Specificity This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIMPDH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}
Synonyms IMPD2
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}
Tissue Location IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor
Research Areas
Citations (0)

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IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.


Sombogaard,F., Pharmacogenet. Genomics 19 (8), 626-634 (2009)
Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)

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$ 295.00
$ 99.00
Cat# AP7390c
(40 western blots)
Availability: In Stock
Bulk Size
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