|Application ||WB, IHC-P, FC, E|
|Calculated MW||62261 Da|
|Antigen Region||130-156 aa|
|Other Names||Gamma-glutamyltransferase 5, GGT 5, Gamma-glutamyl transpeptidase-related enzyme, GGT-rel, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase 5 heavy chain, Gamma-glutamyltransferase 5 light chain, GGT5, GGTLA1|
|Target/Specificity||This GGTLA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-156 amino acids from the N-terminal region of human GGTLA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GGTLA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase.
Heisterkamp,N., Hum. Genet. 123 (4), 321-332 (2008)
Enoiu,M., Free Radic. Biol. Med. 29 (9), 825-833 (2000)
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