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ELF5 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7394c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ELF5 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q9UKW6 |
| Other Accession | Q8VDK3, Q58DT0 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 31263 Da |
ELF5 Antibody (Center) - Additional info | |
| Gene ID 2001 | |
| Other Names ELF5; ESE2; ETS-related transcription factor Elf-5; E74-like factor 5; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2 | |
| Target/Specificity This ELF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186~215 amino acids from the Center region of human ELF5. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ELF5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ELF5 Antibody (Center) - Protein Information | |
| Name ELF5 | |
| Synonyms ESE2 | |
| Function Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | |
| Cellular Location Nucleus (By similarity). | |
| Tissue Location Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression | |
ELF5 Antibody (Center) - Related products
AP7394c: ELF5 Antibody (Center)
DC06002: Human ELF5 cDNA Clone
ELF5 Antibody (Center) - Application data
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Western blot analysis of ELF5 Antibody (Center) (Cat. #AP7394c) in MCF7(lane 1),T47D cell line lysates(lane 2) and mouse lung tissues(lane 3) lysates(35ug/lane). ELF5 (arrow) was detected using the purified Pab.
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Western blot analysis of ELF5 (arrow) using rabbit polyclonal ELF5 Antibody (Center) (Cat. #AP7394c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ELF5 gene.
ELF5 Antibody (Center) - Research Areas
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BACKGROUND
ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus.
REFERENCES
Choi,Y.S., Biochem. J. 398 (3), 497-507 (2006) Tummala,R., J. Cell. Biochem. 97 (4), 766-781 (2006)
