- CITATIONS: 1
|Application ||WB, E|
|Other Accession||Q63379, P03966|
|Calculated MW||49561 Da|
|Antigen Region||322-351 aa|
|Other Names||N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC|
|Target/Specificity||This MYCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human MYCN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYCN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a transcription factor.|
Provided below are standard protocols that you may find useful for product applications.
MYCN is a member of the MYC family and a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of its gene is associated with a variety of tumors, most notably neuroblastomas.
Combaret,V., Pediatr Blood Cancer 53 (3), 329-331 (2009)
Alvarez-Rodriguez,R., J. Cell. Sci. 122 (PT 5), 595-599 (2009)
Jacobs,J.F., BMC Cancer 9, 239 (2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.