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APOA5 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q6Q788 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41213 Da |
| Antigen Region | 22-52 aa |
| Gene ID | 116519 |
|---|---|
| Other Names | Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3 |
| Target/Specificity | This APOA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-52 amino acids from the N-terminal region of human APOA5. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APOA5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOA5 |
|---|---|
| Synonyms | RAP3 |
| Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667). |
| Cellular Location | Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network. Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network |
| Tissue Location | Liver and plasma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
APOA5 is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury.
References
Dorfmeister,B., (er) Arterioscler. Thromb. Vasc. Biol. (2008) In press PUBMED 18635818
Wang,J., (er) Hum. Mol. Genet. (2008) In press
Hubacek,J.A., Clin. Chem. Lab. Med. 46 (6), 773-777 (2008)
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