|Application ||WB, IHC-P, E|
|Calculated MW||41213 Da|
|Antigen Region||22-52 aa|
|Other Names||Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3|
|Target/Specificity||This APOA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-52 amino acids from the N-terminal region of human APOA5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APOA5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.|
|Tissue Location||Liver and plasma.|
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Provided below are standard protocols that you may find useful for product applications.
APOA5 is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury.
Dorfmeister,B., (er) Arterioscler. Thromb. Vasc. Biol. (2008) In press PUBMED 18635818
Wang,J., (er) Hum. Mol. Genet. (2008) In press
Hubacek,J.A., Clin. Chem. Lab. Med. 46 (6), 773-777 (2008)
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