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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Vinculin Antibody (C-term)   

Vinculin Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Vinculin Antibody (C-term) AP7426b
    Anti-VINC Antibody (C-term) at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 124 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - Vinculin Antibody (C-term) AP7426b
    Western blot analysis of anti-Vinculin Antibody (C-term)(Cat.#AP7426b) in mouse lung tissue lysates (35ug/lane). VINC (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18206
Other Accession P85972, P26234, Q64727, P12003
Reactivity Human, Mouse
Predicted Rat, Pig, Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 123799 Da
Antigen Region 1012-1039 aa
Additional Information
Gene ID 7414
Other Names Vinculin, Metavinculin, MV, VCL
Target/Specificity This VINC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1012-1039 amino acids from the C-terminal region of human VINC.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVinculin Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VCL
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity) Colocalizes with LIMD1 in the focal adhesions.
Tissue Location Metavinculin is muscle-specific.
Research Areas
Citations (0)

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VINC is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.


Moiseyeva E.P., Weller P.A.J. Biol. Chem. 268:4318-4325(1993)
Sun N., Critchley D.R., Paulin D.Biochem. J. 409:657-667(2008)
Izard T., Evans G., Borgon R.A.Nature 427:171-175(2004)

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$ 295.00
$ 99.00
Cat# AP7426b
(40 western blots)
Availability: In Stock
Bulk Size
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