|Application ||WB, E|
|Calculated MW||149527 Da|
|Antigen Region||1117-1145 aa|
|Other Names||Multidrug resistance-associated protein 4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, MOAT-B, ABCC4, MRP4|
|Target/Specificity||This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1117-1145 amino acids from the C-terminal region of human ABCC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be an organic anion pump relevant to cellular detoxification.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with particularly high levels in prostate, but is barely detectable in liver|
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Provided below are standard protocols that you may find useful for product applications.
ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Lee K., Belinsky M.G., Bell D.W.Cancer Res. 58:2741-2747(1998)
Adachi M., Sampath J., Lan L.B.J. Biol. Chem. 277:38998-39004(2002)
Kool M., de Haas M., Scheffer G.L.Cancer Res. 57:3537-3547(1997)
Janke D., Mehralivand S., Strand D.Hum. Mutat. 29:659-669(2008)
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