|Application ||WB, IHC-P, FC, E|
|Calculated MW||25913 Da|
|Antigen Region||79-106 aa|
|Other Names||L-xylulose reductase, XR, Carbonyl reductase II, Dicarbonyl/L-xylulose reductase, Kidney dicarbonyl reductase, kiDCR, Sperm surface protein P34H, DCXR|
|Target/Specificity||This DCXR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of human DCXR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCXR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.|
|Cellular Location||Membrane; Peripheral membrane protein. Note=Probably recruited to membranes via an interaction with phosphatidylinositol.|
|Tissue Location||Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DCXR is an enzyme that has both diacetyl reductase and L-xylulose reductase activities.
Nakagawa J., Ishikura S.J. Biol. Chem. 277:17883-17891(2002)
Xia X.Y., Xu X.F., Gao Y.Zhonghua Nan Ke Xue 9:24-27(2003)
El-Kabbani O., Chung R.P.-T.Acta Crystallogr. D 58:1379-1380(2002)
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