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ARSB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P15848 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59687 Da |
| Antigen Region | 235-266 aa |
| Gene ID | 411 |
|---|---|
| Other Names | Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB |
| Target/Specificity | This ARSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-266 amino acids from the Central region of human ARSB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARSB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARSB |
|---|---|
| Function | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). |
| Cellular Location | Lysosome {ECO:0000250|UniProtKB:P50429}. Cell surface {ECO:0000250|UniProtKB:P50429} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ARSB belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B.
References
Peters C., Schmidt B.J. Biol. Chem. 265:3374-3381(1990)
Modaressi S., Rupp K.Biol. Chem. Hoppe-Seyler 374:327-335(1993)
Kobayashi T., Honke K.Biochim. Biophys. Acta 1159:243-247(1992)
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