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CA4 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CA4 Antibody (C-term) AP7479b
    Western blot analysis of CA4 Antibody (C-term) (Cat.#AP7479b) in mouse lung tissue lysates (35ug/lane). CA4 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22748
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35032 Da
Antigen Region 243-272 aa
Additional Information
Gene ID 762
Other Names Carbonic anhydrase 4, Carbonate dehydratase IV, Carbonic anhydrase IV, CA-IV, CA4
Target/Specificity This CA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human CA4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CA4
Function Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels
Research Areas
Citations (0)

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CA4 is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This protein is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, the protein may have a role in inherited renal abnormalities of bicarbonate transport.


Okuyama T., Sato S.Proc. Natl. Acad. Sci. U.S.A. 89:1315-1319(1992) Okuyama T.Genomics 16:678-684(1993) Yang Z., Alvarez B.V.Hum. Mol. Genet. 14:255-265(2005) Okuyama T.Arch. Biochem. Biophys. 320:315-322(1995)

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$ 295.00
$ 99.00
Cat# AP7479b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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