|Application ||WB, IHC-P, FC, IF, E|
|Other Accession||P45846, Q9QZZ6, P19427|
|Predicted||Bovine, Mouse, Pig|
|Calculated MW||24005 Da|
|Antigen Region||102-128 aa|
|Other Names||Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT|
|Target/Specificity||This DPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-128 amino acids from the Central region of human DPT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DPT is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. This protein is found in various tissues and many of its tyrosine residues are sulphated. The protein is postulated to modify the behavior of TGF-beta through interaction with decorin.
Cheung,C.L., Chan,B.Y. Hum. Mol. Genet. 18 (4), 679-687 (2009)
Pochampally,R.R., Ylostalo,J. J. Bone Miner. Res. 22 (9), 1338-1349 (2007)
Lunetta,K.L., D'Agostino,R.B. Sr. BMC Med. Genet. 8 SUPPL 1, S13 (2007)
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