|Application ||WB, E|
|Calculated MW||47402 Da|
|Antigen Region||367-397 aa|
|Other Names||Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR, GHRHR|
|Target/Specificity||This GHRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-397 amino acids from the C-terminal region of human GHRHR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GHRHR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary gland.|
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Provided below are standard protocols that you may find useful for product applications.
GHRHR is a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in GHRHR gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.
Johansson,A., Jonasson,I. PLoS ONE 4 (2), E4464 (2009)
Squire,J., Zhou,A. Genomics 19 (1), 174-175 (1994)
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