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CDKN3 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7528b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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CDKN3 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q16667 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 23805 Da |
CDKN3 Antibody (C-term) - Additional info | |
| Gene ID 1033 | |
| Other Names CDKN3; CDI1; CIP2; KAP; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase | |
| Target/Specificity This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~212 amino acids from the C-terminal region of human CDKN3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CDKN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CDKN3 Antibody (C-term) - Protein Information | |
| Name CDKN3 | |
| Synonyms CDI1, CIP2, KAP | |
| Function May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner | |
| Cellular Location Cytoplasm, perinuclear region. | |
CDKN3 Antibody (C-term) - Related products
AP7528b: CDKN3 Antibody (C-term)
RI10988: CDKN3 predesign siRNA
CDKN3 Antibody (C-term) - Application data
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Western blot analysis of anti-CDKN3 Pab (Cat. #AP7528b) in HL-60 cell lysate. CDKN3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
CDKN3 Antibody (C-term) - Research Areas
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BACKGROUND
CDKN3 belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. The gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.
REFERENCES
Yeh, C.T., et al., Biochem. Biophys. Res. Commun. 305(2):311-314 (2003). Yeh, C.T., et al., Cancer Res. 60(17):4697-4700 (2000). Lee, S.W., et al., Mol. Cell. Biol. 20(5):1723-1732 (2000). Poon, R.Y., et al., Science 270(5233):90-93 (1995). Hannon, G.J., et al., Proc. Natl. Acad. Sci. U.S.A. 91(5):1731-1735 (1994).
