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DYRK1A Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
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|AP7537a||400 µl (40 western blots)||No||Call||DISCONTINUED INQUIRE CLICK INQUIRE Add to cart|
|AP7537a-ev||80 µl (8 western blots)||In Stock||Call||DISCONTINED INQUIRE CLICK INQUIRE Add to cart|
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DYRK1A Antibody (N-term) - Product info
|Other Accession||Q2TAE3, Q63470, Q61214|
|Calculated MW||85584 Da|
DYRK1A Antibody (N-term) - Additional info
|Gene ID 1859|
DYRK1A; DYRK; MNB; MNBH; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog
This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DYRK1A.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
DYRK1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
DYRK1A Antibody (N-term) - Protein Information
|Synonyms DYRK, MNB, MNBH|
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1.
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney
DYRK1A Antibody (N-term) - Application data
Western blot analysis of anti-DYRK1A Antibody (N-term) (Cat.#AP7537a) in mouse liver tissue lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab.
DYRK1A Antibody (C10) (Cat. #AP7537a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the DYRK1A antibody detected the DYRK1A protein (arrow).
DYRK1A Antibody (N-term) - Research Areas
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DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Guimera, J., et al., Genomics 57(3):407-418 (1999). Wang, J., et al., Biochem. Biophys. Res. Commun. 250(3):704-710 (1998). Becker, W., et al., J. Biol. Chem. 273(40):25893-25902 (1998). Dahmane, N., et al., Genomics 48(1):12-23 (1998). Chen, H., et al., Hum. Genet. 99(2):262-265 (1997).