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DYRK1A Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7537a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
DYRK1A Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q13627 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 85584 Da |
DYRK1A Antibody (N-term) - Additional info | |
| Gene ID 1859 | |
| Other Names DYRK1A; DYRK; MNB; MNBH; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog | |
| Target/Specificity This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~32 amino acids from the N-terminal region of human DYRK1A. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions DYRK1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
DYRK1A Antibody (N-term) - Protein Information | |
| Name DYRK1A | |
| Synonyms DYRK, MNB, MNBH | |
| Function May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates | |
| Cellular Location Nucleus speckle. | |
| Tissue Location Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney | |
DYRK1A Antibody (N-term) - Related products
AP7537a: DYRK1A Antibody (N-term)
AP7555a: DYRK1A Antibody (N-term)
AP7555c: DYRK1A Antibody (Center)
RI11645: DYRK1A predesign siRNA
BP7537a: DYRKA Antibody (N-term) Blocking Peptide
DYRK1A Antibody (N-term) - Application data
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Western blot analysis of anti-DYRK1A Antibody (N-term) (Cat.#AP7537a) in mouse liver tissue lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab.
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DYRK1A Antibody (C10) (Cat. #AP7537a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the DYRK1A antibody detected the DYRK1A protein (arrow).
DYRK1A Antibody (N-term) - Research Areas
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BACKGROUND
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
REFERENCES
Guimera, J., et al., Genomics 57(3):407-418 (1999). Wang, J., et al., Biochem. Biophys. Res. Commun. 250(3):704-710 (1998). Becker, W., et al., J. Biol. Chem. 273(40):25893-25902 (1998). Dahmane, N., et al., Genomics 48(1):12-23 (1998). Chen, H., et al., Hum. Genet. 99(2):262-265 (1997).
