|Application ||WB, IHC-P, E|
|Other Accession||Q5RKH1, Q61136, Q08DZ2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||116987 Da|
|Antigen Region||948-978 aa|
|Other Names||Serine/threonine-protein kinase PRP4 homolog, PRP4 kinase, PRP4 pre-mRNA-processing factor 4 homolog, PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K|
|Target/Specificity||This PRP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 948-978 amino acids from the C-terminal region of human PRP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0536, PRP4, PRP4H, PRP4K|
|Function||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.|
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Provided below are standard protocols that you may find useful for product applications.
Pre-mRNA splicing occurs in two sequential transesterification steps, and PRP4 is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).
Dellaire, G., et al., Mol. Cell. Biol. 22(14):5141-5156 (2002).
Kojima, T., et al., J. Biol. Chem. 276(34):32247-32256 (2001).
Huang, Y., et al., Biochem. Biophys. Res. Commun. 271(2):456-463 (2000).
Gross, T., et al., Nucleic Acids Res. 25(5):1028-1035 (1997).
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