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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAPK15 Antibody (N-term)   

MAPK15 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAPK15 Antibody (N-term) AP7554a
    Western blot analysis of ERK8 (arrow) using rabbit polyclonal ERK8 Antibody (N-term) (Cat.#AP7554a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAPK15 gene (Lane 2) (Origene Technologies).
  • WB - MAPK15 Antibody (N-term) AP7554a
    Western blot analysis of anti-ERK8 Antibody (N-term) (Cat.#AP7554a) in T47D cell line lysates (35ug/lane). ERK8 (arrow) was detected using the purified Pab.
  • IHC-P - MAPK15 Antibody (N-term) AP7554a
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ERK8 antibody (N-term)(Cat.#AP7554a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TD08
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59832 Da
Antigen Region 32-61 aa
Additional Information
Gene ID 225689
Other Names Mitogen-activated protein kinase 15, MAP kinase 15, MAPK 15, Extracellular signal-regulated kinase 7, ERK-7, Extracellular signal-regulated kinase 8, ERK-8, MAPK15, ERK7, ERK8
Target/Specificity This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAPK15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK15
Synonyms ERK7, ERK8
Function In vitro, phosphorylates MBP.
Tissue Location Widely expressed with a maximal expression in lung and kidney.
Research Areas
Citations ( 0 )


The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.


Saelzler,M.P., J. Biol. Chem. 281 (24), 16821-16832 (2006)
Iavarone,C., J. Biol. Chem. 281 (15), 10567-10576 (2006)
Klevernic,I.V., Biochem. J. 394 (PT 1), 365-373 (2006)
Suzuki,Y., Genome Res. 14 (9), 1711-1718 (2004)

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$ 295.00
$ 99.00
Cat# AP7554a
(40 western blots)
Availability: In Stock
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