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Thrombopoietin (TPO) Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P40225 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37823 Da |
| Antigen Region | 243-273 aa |
| Gene ID | 7066 |
|---|---|
| Other Names | Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF |
| Target/Specificity | This Thrombopoietin (TPO) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-273 amino acids from the Central region of human Thrombopoietin (TPO). |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Thrombopoietin (TPO) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THPO |
|---|---|
| Synonyms | MGDF |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
References
Baker,J.E.,Cardiovasc. Res. 77 (1), 44-53 (2008)
Steinberg,O.,J. Pediatr. Hematol. Oncol. 29 (12), 822-825 (2007)
Kanayasu-Toyoda,T.,J. Biol. Chem. 282 (46), 33507-33514 (2007)
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