|Application ||WB, E|
|Calculated MW||37823 Da|
|Antigen Region||243-273 aa|
|Other Names||Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF|
|Target/Specificity||This Thrombopoietin (TPO) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-273 amino acids from the Central region of human Thrombopoietin (TPO).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||Thrombopoietin (TPO) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.|
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Provided below are standard protocols that you may find useful for product applications.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
Baker,J.E.,Cardiovasc. Res. 77 (1), 44-53 (2008)
Steinberg,O.,J. Pediatr. Hematol. Oncol. 29 (12), 822-825 (2007)
Kanayasu-Toyoda,T.,J. Biol. Chem. 282 (46), 33507-33514 (2007)
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