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CLIC4 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CLIC4 Antibody AP7564a
    Western blot analysis of CLIC4 (arrow) using rabbit polyclonal CLIC4 Antibody (Cat.#AP7564a).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLIC4 gene (Lane 2) (Origene Technologies).
  • IHC-P - CLIC4 Antibody AP7564a
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CLIC4 antibody (Cat.#AP7564a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y696
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28772 Da
Additional Information
Gene ID 25932
Other Names Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4
Target/Specificity This CLIC4 antibody is generated from rabbits immunized with recombinant human CLIC4 protein.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLIC4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC4
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles
Tissue Location Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle
Research Areas
Citations (0)

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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).


Singh,H.,FEBS J. 274 (24), 6306-6316 (2007)
Suh,K.S.,J. Cell. Sci. 120 (PT 15), 2631-2640 (2007)
Suh,K.S.,Clin. Cancer Res. 13 (1), 121-131 (2007)

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$ 295.00
$ 99.00
Cat# AP7564a
(40 western blots)
Availability: In Stock
Bulk Size
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