- CITATIONS: 5
|Application ||WB, IHC-P, E|
|Calculated MW||57883 Da|
|Antigen Region||453-485 aa|
|Other Names||Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19|
|Target/Specificity||This Aromatase (CYP19A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-485 amino acids from the C-terminal region of human Aromatase (CYP19A1).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Aromatase (CYP19A1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARO1, CYAR, CYP19|
|Function||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|
|Cellular Location||Membrane; Peripheral membrane protein.|
|Tissue Location||Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads|
Provided below are standard protocols that you may find useful for product applications.
CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
Xita,N.,Eur. J. Endocrinol. 158 (6), 861-865 (2008)
Dos Santos,R.M.,(er) DNA Cell Biol. (2008) In press
Nelson,D.R.,Pharmacogenetics 14 (1), 1-18 (2004)
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