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HSPA1A/HSPA1B Antibody (Y41)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HSPA1A/HSPA1B Antibody (Y41) AP7574a
    Western blot analysis of HSPA1A (arrow) using rabbit polyclonal HSPA1A Antibody (S41) (Cat.#AP7574a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HSPA1A gene (Lane 2) (Origene Technologies).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08107
Other Accession P11147, P63018, P63017, P11142, Q90473, P19378, O73885, P19120, P09446, P48741, Q04967, P17066, P22202, P09435, P14659, P17156, P54652, P34933, Q07439, P02827, P08106, P55063, A5A8V7, P16627, Q4R888, P34931, P0CB32, Q6S4N2, P17879, Q27965, Q61696, Q27975
Reactivity Human
Predicted Bovine, Mouse, Pig, Monkey, Rat, Chicken, Xenopus, Yeast, C.Elegans, Hamster, Zebrafish, Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70052 Da
Antigen Region 19-48 aa
Additional Information
Gene ID 3303;3304
Other Names Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70
Target/Specificity This HSPA1A/HSPA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from human HSPA1A/HSPA1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSPA1A/HSPA1B Antibody (Y41) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSPA1, HSX70
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location HSPA1B is testis-specific.
Research Areas
Citations ( 0 )


HSPA1A is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1.


Mueller, T., et al., Transplantation 78(2):292-295 (2004).
Fekete, A., et al., Pediatr. Res. 54(4):452-455 (2003).
Broquet, A.H., et al., J. Biol. Chem. 278(24):21601-21606 (2003).
Bruce, C.R., et al., Diabetes 52(9):2338-2345 (2003).
Anwar, A., et al., J. Biol. Chem. 277(16):14060-14067 (2002).

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$ 295.00
$ 99.00
Cat# AP7574a
(40 western blots)
Availability: In Stock
Bulk Size
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