|Application ||WB, E|
|Calculated MW||14716 Da|
|Other Names||Galectin-1, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, LGALS1|
|Target/Specificity||This LGALS1 antibody is generated from rabbits immunized with human recombinant GLT protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LGALS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level) Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation.
Bi,S.,J. Biol. Chem. 283 (18), 12248-12258 (2008)
Le Mercier,M., J. Neuropathol. Exp. Neurol. 67 (5), 456-469 (2008)
Pacienza,N., FASEB J. 22 (4), 1113-1123 (2008)
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