|Application ||WB, IHC-P, E|
|Other Accession||O88751, Q9JLK7, Q9N1R0|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||39838 Da|
|Antigen Region||311-343 aa|
|Other Names||Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1|
|Target/Specificity||This CABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-343 amino acids from the C-terminal region of human CABP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CABP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S-CaBP1 is localized at or near the plasma membrane|
|Tissue Location||Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum|
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Provided below are standard protocols that you may find useful for product applications.
CABP1 belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this protein was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina.
Haynes,L.P., Proteomics 6 (6), 1822-1832 (2006) Wingard,J.N., J. Biol. Chem. 280 (45), 37461-37470 (2005) Zhou,H., J. Biol. Chem. 280 (33), 29612-29619 (2005) Haeseleer,F., J. Biol. Chem. 275 (2), 1247-1260 (2000)
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