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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLIC1 Antibody   

CLIC1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - CLIC1 Antibody AP7589a
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CLIC1 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - CLIC1 Antibody AP7589a
    Western blot analysis of anti-CLIC1 Antibody (Cat.#AP7589a) in A375 cell line lysates (35ug/lane). CLIC1(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00299
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 26923 Da
Additional Information
Gene ID 1192
Other Names Chloride intracellular channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regulatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27
Target/Specificity This CLIC1 antibody is generated from rabbits immunized with a recombinant human CLIC1 protein.
Dilution IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLIC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC1
Synonyms G6, NCC27
Function Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Cellular Location Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain
Tissue Location Expression is prominent in heart, placenta, liver, kidney and pancreas.
Research Areas
Citations (0)

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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.


Singh,H., FEBS J. 274 (24), 6306-6316 (2007)
Ulmasov,B., (er) BMC Cell Biol. 8, 8 (2007)
Edwards,J.C., J. Membr. Biol. 213 (1), 39-46 (2006)

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$ 295.00
$ 99.00
Cat# AP7589a
(40 western blots)
Availability: In Stock
Bulk Size
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