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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AXL Antibody   

AXL Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AXL Antibody AP7602d
    Western blot analysis of anti-AXL Antibody (Cat.#AP7602d) in A375 cell line lysates (35ug/lane). AXL(arrow) was detected using the purified Pab.
  • IHC-P - AXL Antibody AP7602d
    Formalin-fixed and paraffin-embedded human colon carcinoma with AXL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - AXL Antibody AP7602d
    Flow cytometric analysis of WiDr cells using AXL Antibody(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30530
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 98336 Da
Additional Information
Gene ID 558
Other Names Tyrosine-protein kinase receptor UFO, AXL oncogene, AXL, UFO
Target/Specificity This AXL antibody is generated from rabbits immunized with a his tag recombinant protein of human AXL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAXL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AXL
Synonyms UFO
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Research Areas
Citations (0)

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AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.


Lee, S.T., et al., Oncogene 8(12):3403-3410 (1993). Janssen, J.W., et al., Oncogene 6(11):2113-2120 (1991). O'Bryan, J.P., et al., Mol. Cell. Biol. 11(10):5016-5031 (1991). Partanen, J., et al., Proc. Natl. Acad. Sci. U.S.A. 87(22):8913-8917 (1990).

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$ 295.00
$ 99.00
Cat# AP7602d
(40 western blots)
Availability: In Stock
Bulk Size
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