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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LUM Antibody (Center)   

LUM Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LUM Antibody (Center) AP7605c
    Western blot analysis of LUM antibody (Center) (Cat.#AP7605c) in A375 cell line lysates (35ug/lane). LUM (arrow) was detected using the purified Pab.
  • IHC-P - LUM Antibody (Center) AP7605c
    Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with LUM Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - LUM Antibody (Center) AP7605c
    LUM Antibody (Center) (Cat. #AP7605c) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P51884
Other Accession P51885, Q05443
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38429 Da
Antigen Region 198-227 aa
Additional Information
Gene ID 4060
Other Names Lumican, Keratan sulfate proteoglycan lumican, KSPG lumican, LUM, LDC, SLRR2D
Target/Specificity This LUM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the Central region of human LUM.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLUM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LUM
Synonyms LDC, SLRR2D
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Cornea and other tissues.
Research Areas
Citations (0)

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Background

LUM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, this protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. The protein is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

References

Wang,P., Li,S. Invest. Ophthalmol. Vis. Sci. 50 (4), 1546-1551 (2009)
Matsuda,Y., Yamamoto,T. Int. J. Oncol. 33 (6), 1177-1185 (2008)
Kelemen,L.E., Couch,F.J. Breast Cancer Res. 10 (6), R98 (2008)

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$ 295.00
$ 99.00
Cat# AP7605c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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