|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||P28841, Q03333, P21661|
|Calculated MW||70565 Da|
|Antigen Region||87-116 aa|
|Other Names||Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2, PCSK2, NEC2|
|Target/Specificity||This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human PCSK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PCSK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
Leak,T.S., Keene,K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007)
Shen,X., Li,Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005)
Tzimas,G.N., Chevet,E. BMC Cancer 5, 149 (2005)
Seidah,N.G., Mattei,M.G. Genomics 11 (1), 103-107 (1991)
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