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POLDIP2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - POLDIP2 Antibody (C-term) AP7626B
    Western blot analysis of POLDIP2 antibody (C-term) (Cat.#AP7626b) in mouse kidney tissue lysates (35ug/lane). POLDIP2 (arrow) was detected using the purified Pab.
    detail
  • WB - POLDIP2 Antibody (C-term) AP7626B
    Western blot analysis of POLDIP2 (arrow) using rabbit polyclonal POLDIP2 Antibody (C-term) (Cat. #AP7626b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the POLDIP2 gene.
    detail
  • FC - POLDIP2 Antibody (C-term) AP7626B
    POLDIP2 Antibody (C-term) (Cat. #AP7626b) flow cytometry analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q9Y2S7
Other Accession Q91VA6
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42033 Da
Antigen Region 320-349 aa
Additional Information
Gene ID 26073
Other Names Polymerase delta-interacting protein 2, 38 kDa DNA polymerase delta interaction protein, p38, POLDIP2, PDIP38, POLD4
Target/Specificity This POLDIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-349 amino acids from the C-terminal region of human POLDIP2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPOLDIP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POLDIP2 {ECO:0000303|PubMed:26984527, ECO:0000312|HGNC:HGNC:23781}
Function Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527).
Cellular Location Mitochondrion matrix. Nucleus Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus.
Citations (0)
citation

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Background

POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein also interacts with proliferating cell nuclear antigen. Some transcripts of POLDIP2 gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).

References

Bogenhagen,D.F., J. Biol. Chem. 283 (6), 3665-3675 (2008)
Klaile,E., J. Biol. Chem. 282 (36), 26629-26640 (2007)
Cheng,X., J. Biochem. 138 (6), 673-678 (2005)

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$ 365.00
$ 140.00
Cat# AP7626B
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