- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
FGFR1 Antibody (Y766)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP7636f | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
FGFR1 Antibody (Y766) - Product info | |
| Application | WB
|
| Primary Accession | P11362 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 91868 Da |
FGFR1 Antibody (Y766) - Additional info | |
| Gene ID 2260 | |
| Other Names FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; Fms-like tyrosine kinase 2; N-sam; Proto-oncogene c-Fgr; CD_antigen=CD331; Flags: Precursor | |
| Target/Specificity This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y766 of human FGFR1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions FGFR1 Antibody (Y766) is for research use only and not for use in diagnostic or therapeutic procedures. | |
FGFR1 Antibody (Y766) - Protein Information | |
| Name FGFR1 | |
| Synonyms BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR | |
| Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2 In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation | |
| Cellular Location Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus | |
| Tissue Location Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells | |
FGFR1 Antibody (Y766) - Related products
AP3104a: Phospho-FGFR-pY653/654 Antibody
AP3105a: Phospho-FGFR-Y766 Antibody
AP3105b: Phospho-FGFR1-pY766 Antibody
AP3311a: Phospho-FGFR1-Y307 Antibody
AP3312a: Phospho-FGFR1-Y463 Antibody
AP3313a: Phospho-FGFR1-Y654 Antibody
AP3420a: Phospho-FGFR1-pY154 Antibody
AP3755a: Phospho-FGFR- Y653 Antibody
AP7636b: FGFR1 Antibody (C-term)
AP7636d: FGFR1 Antibody (Y463)
AP7636e: FGFR1 Antibody (Y654)
AP7636f: FGFR1 Antibody (Y766)
AP7636g: FGFR1 Antibody (Y653)
AP7636h: FGFR1 Antibody (Y154)
AP7636i: FGFR1 Antibody (C-term)
RI11993: FGFR1 predesign siRNA
LY10425a: FGFR1 Over-expression Lysate
BP3104a: Phospho-FGFR-Y653/654 Antibody Blocking Peptide
BP3105a: Phospho-FGFR-Y766 Antibody Blocking Peptide
BP3105b: Phospho-FGFR1-pY766 Antibody Blocking Peptide
BP3311a: Phospho-FGFR1-Y307 Antibody Blocking Peptide
BP3312a: Phospho-FGFR1-Y463 Antibody Blocking Peptide
BP3313a: Phospho-FGFR1-Y654 Blocking Peptide
BP3420a: Phospho-FGFR1-pY154 Antibody Blocking Peptide
BP7636a: FGFR1 Antibody (N-term) Blocking Peptide
BP7636b: FGFR1 Antibody (C-term) Blocking Peptide
BP7636d: FGFR1 Antibody (Y463) Blocking Peptide
BP7636e: FGFR1 Antibody (Y654) Blocking Peptide
BP7636f: FGFR1 Antibody (Y766) Blocking Peptide
BP7636g: FGFR1 Antibody (Y653) Blocking Peptide
BP7636h: FGFR1 Antibody (Y154) Blocking Peptide
BP9814a: FGFR1-Y307 Antibody Blocking Peptide
FGFR1 Antibody (Y766) - Application data
-
Western blot analysis of FGFR1 (arrow) using rabbit polyclonal FGFR1 Antibody (Y766) (RB11274). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2) (Origene Technologies).
FGFR1 Antibody (Y766) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.
REFERENCES
Jiao, J., et al., Arch. Biochem. Biophys. 410(2):187-200 (2003). Fu, L., et al., J. Comp. Neurol. 462(2):265-273 (2003). Lundin, L., et al., Exp. Cell Res. 287(1):190-198 (2003). Kiselyov, V.V., et al., Structure (Camb.) 11(6):691-701 (2003). Baumann, H., et al., J. Biol. Chem. 278(18):16198-16208 (2003).
