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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ILK Antibody (T173)   

ILK Antibody (T173)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ILK Antibody (T173) AP7651f
    Western blot analysis of anti-ILK Antibody (T173) (RB13894) in NCI-H460 cell line lysates (35ug/lane). EN1(arrow) was detected using the purified Pab.
  • IHC-P - ILK Antibody (T173) AP7651f
    Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with ILK Antibody (T173) (Cat.#AP7651f) antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13418
Other Accession Q99J82, O55222, Q3SWY2, NP_004508
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51419 Da
Antigen Region 151-180 aa
Additional Information
Gene ID 3611
Other Names Integrin-linked protein kinase, 59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK, ILK, ILK1, ILK2
Target/Specificity This ILK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from human ILK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsILK Antibody (T173) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ILK
Synonyms ILK1, ILK2
Function Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Cellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere
Tissue Location Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver
Research Areas
Citations (0)

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Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK is a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.


Li, Y., et al., J. Clin. Invest. 112(4):503-516 (2003).
Troussard, A.A., et al., J. Biol. Chem. 278(25):22374-22378 (2003).
Marotta, A., et al., Br. J. Cancer 88(11):1755-1762 (2003).
Cordes, N., et al., Br. J. Cancer 88(9):1470-1479 (2003).
Fukuda, T., et al., J. Cell Biol. 160(7):1001-1008 (2003).

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$ 295.00
$ 99.00
Cat# AP7651f
(40 western blots)
Availability: In Stock
Bulk Size
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