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MPST Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MPST Antibody (C-term) AP7652b
    Western blot analysis of MPST antibody (C-term) (Cat.#AP7652b) in HepG2閿涘潤ane 1閿涘¨nd Hela(lane2 ) cell line lysates (35ug/lane). MPST (arrow) was detected using the purified Pab.
    detail
  • WB - MPST Antibody (C-term) AP7652b
    Western blot analysis of MPST antibody (C-term) (Cat.#AP7652b) in mouse liver tissue lysates (35ug/lane). MPST (arrow) was detected using the purified Pab.
    detail
  • FC - MPST Antibody (C-term) AP7652b
    MPST Antibody (C-term) (Cat. #AP7652b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession P25325
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33178 Da
Antigen Region 269-297 aa
Additional Information
Gene ID 4357
Other Names 3-mercaptopyruvate sulfurtransferase, MST, MPST, TST2
Target/Specificity This MPST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-297 amino acids from the C-terminal region of human MPST.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMPST Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MPST
Synonyms TST2
Function Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000250|UniProtKB:P97532}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q99J99}
Research Areas
Citations ( 0 )

Background

MPST catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU).

References

Billaut-Laden,I., Toxicol. Lett. 165 (2), 101-111 (2006)

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$ 182.50
$ 70.00
Cat# AP7652b
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