- CITATIONS: 1
|Application ||WB, FC, E|
|Calculated MW||33178 Da|
|Antigen Region||269-297 aa|
|Other Names||3-mercaptopyruvate sulfurtransferase, MST, MPST, TST2|
|Target/Specificity||This MPST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-297 amino acids from the C-terminal region of human MPST.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPST Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity).|
|Cellular Location||Cytoplasm. Mitochondrion. Cell junction, synapse, synaptosome|
Provided below are standard protocols that you may find useful for product applications.
MPST catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU).
Billaut-Laden,I., Toxicol. Lett. 165 (2), 101-111 (2006)
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