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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CPE Antibody (C-term)   

CPE Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CPE Antibody (C-term) AP7657b
    Western blot analysis of CPE antibody (C-term) (Cat.#AP7657b) in mouse cerebellum tissue lysates (35ug/lane). CPE (arrow) was detected using the purified Pab.
  • WB - CPE Antibody (C-term) AP7657b
    Western blot analysis of CPE antibody (C-term)(Cat.#AP7657b) in Hela cell line lysates (35ug/lane). CPE (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16870
Other Accession Q4R4M3, P04836
Reactivity Human, Mouse
Predicted Bovine, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53151 Da
Antigen Region 381-412 aa
Additional Information
Gene ID 1363
Other Names Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE
Target/Specificity This CPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human CPE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPE
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Cellular Location Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Tissue Location Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas
Research Areas
Citations (0)

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CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in CPE gene are implicated in type II diabetes.


Oiso,S., J. Neurochem. 109 (1), 158-167 (2009)
Yang,L., Ann. N. Y. Acad. Sci. 1150, 263-266 (2008)
Jeffrey,K.D., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8452-8457 (2008)

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$ 295.00
$ 99.00
Cat# AP7657b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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