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PDGFRA Antibody (Y768)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7666h | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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PDGFRA Antibody (Y768) - Product info | |
| Application | WB, IHC
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| Primary Accession | P16234 |
| Other Accession | NP_006197 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 122670 Da |
PDGFRA Antibody (Y768) - Additional info | |
| Gene ID 5156 | |
| Other Names PDGFRA; PDGFR2; RHEPDGFRA; Platelet-derived growth factor receptor alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; CD_antigen=CD140a; Flags: Precursor | |
| Target/Specificity This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y768 of human PDGFRA. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PDGFRA Antibody (Y768) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PDGFRA Antibody (Y768) - Protein Information | |
| Name PDGFRA | |
| Synonyms PDGFR2, RHEPDGFRA | |
| Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor | |
| Cellular Location Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly internalized and degraded | |
| Tissue Location Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue | |
PDGFRA Antibody (Y768) - Related products
AP3329a: Phospho-PDGFRA-Y574 Antibody
AP3330a: Phospho-PDGFRA-Y762 Antibody
AP3331a: Phospho-PDGFRA-Y1018 Antibody
AP3410a: Phospho-PDGFRA-pY754 Antibody
AP3412a: Phospho-PDGFRA-pY988 Antibody
AP3506a: Phospho-PDGFRA-pY572 Antibody
AP7666b: PDGFRA Antibody (C-term E1063)
AP7666d: PDGFRA Antibody (Y720)
AP7666f: PDGFRA Antibody (Y762)
AP7666g: PDGFRA Antibody (S767)
AP7666h: PDGFRA Antibody (Y768)
AP7666i: PDGFRA Antibody (Y574)
AP7666j: PDGFRA Antibody (Y754)
AP7666k: PDGFRA Antibody (Y988)
AP7666l: PDGFRA Antibody (Y1018)
AP7666m: PDGFRA Antibody (Y572)
RI13882: PDGFRA predesign siRNA
DC04038: Human PDGFRA cDNA Clone
LY10723a: PDGFRA Over-expression Lysate
BP3329a: Phospho-PDGFRA-Y574 Antibody Blocking Peptide
BP3330a: Phospho-PDGFRA-Y762 Antibody Blocking Peptide
BP3331a: Phospho-PDGFRA-Y1018 Antibody Blocking Peptide
BP3410a: Phospho-PDGFRA-pY754 Antibody Blocking Peptide
BP3412a: Phospho-PDGFRA-pY988 Antibody Blocking Peptide
BP3506a: Phospho-PDGFRA-pY572 Antibody Blocking Peptide
BP7666b: PDGFRA Antibody (C-term E1063) Blocking Peptide
BP7666d: PDGFRA Antibody (Y720) Blocking Peptide
BP7666f: PDGFRA Antibody (Y762) Blocking Peptide
BP7666g: PDGFRA Antibody (S767) Blocking Peptide
BP7666h: PDGFRA Antibody (Y768) Blocking Peptide
BP7666i: PDGFRA Antibody (Y574) Blocking Peptide
BP7666j: PDGFRA Antibody (Y754) Blocking Peptide
BP7666k: PDGFRA Antibody (Y988) Blocking Peptide
PDGFRA Antibody (Y768) - Application data
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Western blot analysis of PDGFRA (arrow) using rabbit polyclonal PDGFRA Antibody (Y768) (RB11119). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDGFRA gene (Lane 2) (Origene Technologies).
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Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PDGFRA Antibody (Y768), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
PDGFRA Antibody (Y768) - Research Areas
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BACKGROUND
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
REFERENCES
Wilczynski, S.P., et al., Hum. Pathol. 36(3):242-249 (2005). Hiwatari, M., et al., Leukemia 19(3):476-477 (2005). Debiec-Rychter, M., et al., Gastroenterology 128(2):270-279 (2005). Sakurai, S., et al., Hum. Pathol. 35(10):1223-1230 (2004). Subramanian, S., et al., Oncogene 23(47):7780-7790 (2004).
