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TYRO3 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7679a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP7679a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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TYRO3 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q06418 |
| Other Accession | NP_006284 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 96905 Da |
TYRO3 Antibody (N-term) - Additional info | |
| Gene ID 7301 | |
| Other Names TYRO3; SKY; BYK; DTK; RSE; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase byk | |
| Target/Specificity This TYRO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41~70 amino acids from the N-terminal region of human SKY. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TYRO3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TYRO3 Antibody (N-term) - Protein Information | |
| Name TYRO3 | |
| Synonyms BYK, DTK, RSE, SKY, TIF | |
| Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 | |
| Cellular Location Cell membrane; Single-pass type I membrane protein | |
| Tissue Location Abundant in the brain and lower levels in other tissues | |
TYRO3 Antibody (N-term) - Related products
AP7679a: TYRO3 Antibody (N-term)
AP7679b: TYRO3 Antibody (C-term)
RI15556: TYRO3 predesign siRNA
BP7679a: SKY Antibody (N-term) Blocking Peptide
BP7679b: SKY Antibody (C-term) Blocking Peptide
TYRO3 Antibody (N-term) - Application data
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Western blot analysis of anti-SKY Pab (Cat. #AP7679a) in mouse brain lysate. SKY (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
TYRO3 Antibody (N-term) - Research Areas
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BACKGROUND
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
REFERENCES
Dey, B.R., et al., Gene 209 (1-2), 175-183 (1998).
