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CDK5R1(p35) Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7743b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
CDK5R1(p35) Antibody (C-term) - Product info | |
| Application | IHC, WB
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| Primary Accession | Q15078 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 34060 Da |
CDK5R1(p35) Antibody (C-term) - Additional info | |
| Gene ID 8851 | |
| Other Names CDK5R1; CDK5R; NCK5A; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 activator 1, p25; Tau protein kinase II 23 kDa subunit | |
| Target/Specificity This CDK5R1(p35) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278~307 amino acids from the C-terminal region of human CDK5R1. | |
| Dilution IHC~~1:10~50 WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CDK5R1(p35) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CDK5R1(p35) Antibody (C-term) - Protein Information | |
| Name CDK5R1 | |
| Synonyms CDK5R, NCK5A | |
| Function p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII | |
| Cellular Location Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals | |
| Tissue Location Brain and neuron specific. | |
CDK5R1(p35) Antibody (C-term) - Related products
AP7743b: CDK5R1(p35) Antibody (C-term)
RI10970: CDK5R1 predesign siRNA
CDK5R1(p35) Antibody (C-term) - Application data
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Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody (C-term) (Cat.#AP7743b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CDK5R1 Antibody (C-term) (Cat. #AP7743b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CDK5R1 antibody detected the CDK5R1 protein (arrow).
CDK5R1(p35) Antibody (C-term) - Research Areas
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BACKGROUND
p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
REFERENCES
Lin,S., FEBS Lett. 582 (8), 1197-1202 (2008) Sen,A., Neuroreport 18 (5), 511-516 (2007) Mitsios,N., Brain Pathol. 17 (1), 11-23 (2007)
