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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   ANTXR1 Antibody (Y382)   

ANTXR1 Antibody (Y382)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ANTXR1 Antibody (Y382) AP7746a
    Western blot analysis of anti-ANTXR1 Antibody (Y382)(Cat.#AP7746a) in Hela cell line lysates (35ug/lane). ANTXR1 (arrow) was detected using the purified Pab.
  • IHC-P - ANTXR1 Antibody (Y382) AP7746a
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANTXR1 Antibody (Y382) (Cat.#AP7746a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H6X2
Other Accession Q6DFX2, P58335, Q0PMD2, Q9CZ52
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62789 Da
Antigen Region 358-386 aa
Additional Information
Gene ID 84168
Other Names Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Target/Specificity This ANTXR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-386 amino acids from human ANTXR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsANTXR1 Antibody (Y382) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ATR, TEM8
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
Cellular Location Cell membrane; Single-pass type I membrane protein Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia
Tissue Location Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells
Research Areas
Citations (0)

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ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.


Werner,E., J. Biol. Chem. 281 (32), 23227-23236 (2006)
Wei,W., Cell 124 (6), 1141-1154 (2006)
Rainey,G.J., Proc. Natl. Acad. Sci. U.S.A. 102 (37), 13278-13283 (2005)

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$ 295.00
$ 99.00
Cat# AP7746a
(40 western blots)
Availability: In Stock
Bulk Size
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