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TIEG Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TIEG Antibody (N-term) AP7749a
    All lanes : Anti-TIEG Antibody (N-term) at 1:2000 dilution Lane 1: 293T whole cell lysates Lane 2: MCF-7 whole cell lysates Lane 3: human kidney lysates Lane 4: human lung lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - TIEG Antibody (N-term) AP7749a
    Western blot analysis of anti-TIEG Antibody (N-term) (Cat.#AP7749a) pre-incubated with and without blocking peptide in CEM cell line lysate. TIEG(N-term)(arrow) was detected using the purified Pab .
  • IHC-P - TIEG Antibody (N-term) AP7749a
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with TIEG antibody (N-term) (Cat.#AP7749a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13118
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52555 Da
Antigen Region 13-40 aa
Additional Information
Gene ID 7071
Other Names Krueppel-like factor 10, EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1, KLF10, TIEG, TIEG1
Target/Specificity This TIEG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TIEG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIEG Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF10
Synonyms TIEG, TIEG1
Function Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
Cellular Location Nucleus {ECO:0000250|UniProtKB:O89091}.
Research Areas
Citations (0)

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TIEG is a transcriptional repressor involved in the regulation of cell growth. TIEG binds to the consensus sequence 5'-GGTGTG-3'and inhibits cell growth.


Hawse,J.R., Mol. Endocrinol. 22 (7), 1579-1595 (2008)
Ivanov,S.V., Biochem. Biophys. Res. Commun. 370 (4), 536-540 (2008)
Jin,W., FEBS Lett. 581 (20), 3826-3832 (2007)
Fueki,N., Respiration 74 (4), 454-459 (2007)

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$ 295.00
$ 99.00
Cat# AP7749a
(40 western blots)
Availability: In Stock
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