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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARHE Antibody (Center)   

ARHE Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ARHE Antibody (Center) AP7751c
    All lanes : Anti-ARHE Antibody (Center) at 1:2000 dilution Lane 1: mouse brain lysate Lane 2: rat brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ARHE Antibody (Center) AP7751c
    Western blot analysis of ARHE Antibody (Center)(Cat. 3AP7751c) in mouse brain tissue lysates (35ug/lane). ARHE (arrow) was detected using the purified Pab.
  • IHC-P - ARHE Antibody (Center) AP7751c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ARHE antibody (Center) (Cat.#AP7751c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61587
Other Accession Q6SA80, O77683, P61588
Reactivity Human, Mouse, Rat
Predicted Rat, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27368 Da
Antigen Region 133-165 aa
Additional Information
Gene ID 390
Other Names Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3, RND3, ARHE, RHO8, RHOE
Target/Specificity This ARHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the Central region of human ARHE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARHE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RND3
Synonyms ARHE, RHO8, RHOE
Function Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
Cellular Location Golgi apparatus membrane; Peripheral membrane protein
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]).


Pinner,S., Nat. Cell Biol. 10 (2), 127-137 (2008)
Poch,E., Exp. Cell Res. 313 (4), 719-731 (2007)
Ongusaha,P.P., Curr. Biol. 16 (24), 2466-2472 (2006)

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$ 295.00
$ 99.00
Cat# AP7751c
(40 western blots)
Availability: In Stock
Bulk Size
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