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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   FKBP1A Antibody (C-term)   

FKBP1A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FKBP1A Antibody (C-term) AP7756B
    Western blot analysis of FKBP1A antibody (C-term) (Cat.# AP7756b) in Jurkat cell line lysates (35ug/lane). FKBP1A (arrow) was detected using the purified Pab.
  • IHC-P - FKBP1A Antibody (C-term) AP7756B
    FKBP1A Antibody (C-term) (Cat.# AP7756b) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FKBP1A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • WB - FKBP1A Antibody (C-term) AP7756B
    Western blot analysis of FKBP1A (arrow) using rabbit polyclonal FKBP1A Antibody (C-term) (Cat. #AP7756b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FKBP1A gene.
  • FC - FKBP1A Antibody (C-term) AP7756B
    FKBP1A Antibody (C-term) (Cat. #AP7756b) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62942
Other Accession P62943, P18203
Reactivity Human
Predicted Rabbit, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 11951 Da
Antigen Region 55-83 aa
Additional Information
Gene ID 2280
Other Names Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, Calstabin-1, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, FKBP1A, FKBP1, FKBP12
Target/Specificity This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFKBP1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FKBP1, FKBP12
Function Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.


Gerard,M., J. Neurochem. 106 (1), 121-133 (2008)
Shor,B., Cancer Res. 68 (8), 2934-2943 (2008)
Jayaraman,T.,J. Biol. Chem. 267 (14), 9474-9477 (1992)

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$ 295.00
$ 99.00
Cat# AP7756B
(40 western blots)
Availability: In Stock
Bulk Size
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