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SEMA3A Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SEMA3A Antibody (Center) AP7760c
    Western blot analysis of SEMA3A Antibody (Center) (Cat. #AP7760c) in CEM cell line lysates (35ug/lane). SEMA3A (arrow) was detected using the purified Pab.
  • IHC-P - SEMA3A Antibody (Center) AP7760c
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SEMA3A antibody (Center) (Cat.#AP7760c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14563
Other Accession Q63548, O08665, Q90607
Reactivity Human
Predicted Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 88889 Da
Antigen Region 535-566 aa
Additional Information
Gene ID 10371
Other Names Semaphorin-3A, Semaphorin III, Sema III, SEMA3A, SEMAD
Target/Specificity This SEMA3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-566 amino acids from the Central region of human SEMA3A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEMA3A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SEMAD
Function Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
Cellular Location Secreted.
Research Areas
Citations (0)

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SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.


Narazaki,M., Blood 111 (8), 4126-4136 (2008)
Tannemaat,M.R., J. Neurosci. 27 (52), 14260-14264 (2007)
Appleton,B.A., EMBO J. 26 (23), 4902-4912 (2007)

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$ 295.00
$ 99.00
Cat# AP7760c
(40 western blots)
Availability: In Stock
Bulk Size
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