|Application ||FC, WB, E|
|Other Accession||P25435, P18280, Q06AV0, P20181, P25433, Q08DT3|
|Reactivity||Human, Mouse, Rat|
|Predicted||Bovine, Chicken, Pig, Xenopus|
|Calculated MW||29355 Da|
|Antigen Region||152-184 aa|
|Other Names||Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor, NTF3|
|Target/Specificity||This NTF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-184 amino acids from the C-terminal region of human NTF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NTF3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to promote the survival of visceral and proprioceptive sensory neurons.|
|Tissue Location||Brain and peripheral tissues.|
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Provided below are standard protocols that you may find useful for product applications.
NTF3 is a member of the neurotrophin family that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Hossain,W.A., J. Neurosci. Res. 86 (11), 2376-2391 (2008)
Mercader,J.M., Hum. Mol. Genet. 17 (9), 1234-1244 (2008)
Kalcheim,C.,Proc. Natl. Acad. Sci. U.S.A. 89 (5), 1661-1665 (1992)
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